![]() | Only 14 pages are availabe for public view |
Abstract Breast cancer represents the second most common cancer over world and accounts for 25% of all cancer cases and 15% of all cancer deaths among females. The main types of treatment for breast cancer are surgery, radiation therapy, chemotherapy, hormone therapy and targeted therapy. The main chemotherapy adverse effects such as hair loss, depressed immunity and fatigue have a negative impact on health related quality of life.On the other hand, nanoparticles (NPs) show interesting characteristics as small sizes, large surface-to-volume ratios, high drug loading, self-assembly capacity, and biocompatibility. Thus, they confer specific physical and chemical properties at the cellular and molecular levels not attainable with the drug moieties.Natural polymers as polysaccharides and proteins have superior properties or synthetic polymers as polymers for drug delivery systems including biodegradability, non-antigenicity and compatibility.This study focuses on the development of NCs (nanocapsules) for the co-delivery of two anticancer agents. The NCs are conjugated to CdTe QDs (cadmium telluride quantum dots) to enable imaging of tumor tissues and ensure localization of NCs in the tumor. |