الفهرس 
Cover EnglishOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a commonly encountered chronic dermatological disease, presenting with inflammatory symptoms in patients. Systemic treatment of psoriasis is associated with several adverse effects;therefore the development of a customized opical treatment modality for psoriasis would be an interesting alternative to ystemic delivery. The therapeutic modality explored in this studywas the comparative treatment of psoriatic patients using nanoparticulated methotrexatein the form of jojoba oil based microemulsion with or without fractional erbium YAG laser.Assessment parameters included follow up photography for up to 8 weeks of treatment, estimationof the psoriasis severityscoreof the treated lesionswhich is the score of thickness, erythema, scales (TES score), and histopathological skin evaluation. Results revealed that the prepared methotrexate microemulsion was clinically beneficial and safe in treatment of psoriasis vfractional laser provided improvement in the duration (3 weeks compared to 8 weeks of topical treatment modality for psoriasis vulgaris.