الفهرس 
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Abstract
Introduction Osteoarthritis and rheumatoid arthritis are the most common types of arthritis.Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder that is characterized by polyarthritis with progressive joint damage and disability. Osteoarthritis (OA) is a widespread chronic joint disease that leads to long-term disability. Leptin is one of the cytokines secreted by adipocytes especially from abdomen adipose tissue (adipokines).
The aim of the work was to measure the serum leptin level in patients with rheumatoid arthritis, and knee osteoarthritis and correlate it with RA and knee OA severity.
The study included 30 RA patients with mean age (45.9 ± 13.14) years and 30 1ry knee OA patients with mean age (52.37 ± 7.36) years and 30 healthy controls with mean age (39.5 ± 12.58) years. Patients with one or more of the followings were excluded:
• Patients with secondary OA.
• Patients with other rheumatological diseases.
• Patients taking medication known to affect the nutritional status or regulation of fat metabolism.
Methods:
Serum leptin level and anthropometric data were obtained from all 90 subjects. The studied RA and OA patients were assessed by detailed history taking and complete clinical examination with special stress on muscloskletal examination and the Modified Stanford Health Assessment Questionnaire disability index MHAQ-DI. In (RA) patients the Disease activity was assessed by Disease activity score with 28 joints count (DAS-28) and radiological changes were assessed by Plain X-ray of both hands using Sharp/van der Heijde (SvdH) scoring method. In (OA) patients disability and pain severity were assessed using Western Ontario and Mcmaster Universities Osteoarthritis index (WOMAC) and radiological severity was assessed by Kellgren and Laurance global scale.