الفهرس 
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Abstract
Obesity is a global health issue and in recent years its prevalence has increased dramatically,in 2014, more than 1.9 billion adults 18 years and older were overweight.
The present study reported a statistically significant increase in body weights in G2in comparison to G1 indicating that obesity in male albino rats was successfully induced via administration of a HFD, there was also, astatistically significant increase in TC, TGand LDL-Clevels, as well as a decrease in HDL-Clevels in G2 was observed, indicating that HLP (hyperlipidemia) was also induced in the same group of rats, in comparison to G 1.
The high fat content diet for 6 months caused accumulation of lipids within the hepatocytes of the rats (NAFLD).By administration ofcurcumin, hepatocytes showed apparent decrease in cytoplasmic vacuoles due to decreased fat accumulation.
In this study, there wasastatistically significant decrease in body weightsin G3, G4 and G5 compared with G2 after administration of curcumin in a dose of (100mg/kg body weight), there wasalso a statistically significant decrease in the serum TC, TG and LDL-C levelsin the same groups.
It was observed that obesity is associated with poor iron status as evidenced by statistically significant decreased serum iron, and increase in serum ferritin and hepcidin in obese G 2 and G6.
There was also significant decrease in serum iron in curcumin treated groups (G3, G4, G5) when compared to G1.
VII- 2- Conclusion
In conclusion, administration of curcumin was found to decrease the body weight, serum and liver levels of TC, TG and LDL-C. In addition, curcumin increased the levels of HDL-C. Thus, administration of curcumin is beneficial against HLP.
Hepcidin plays a central role in the anemia of chronic disease and Hepcidin overproduction even in mild inflammatory disorder as obesity may explain the association of poor iron status with obesity.
There is a potentially adverse biological activity of high-dose curcumin supplementation that might lead to impaired iron absorption and status.