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العنوان
Phytochemical investigation and biological screening of some Egyptian medicinal plants /
المؤلف
Gadallah, Adel Saied Ahmed Mohammed.
هيئة الاعداد
باحث / عادل سعيد أحمد محمد جادالله
مشرف / هشام رشدي الصعيدي
مشرف / محمد إقبال شودري
مشرف / شادين على محمود خليفة
الموضوع
Medicinal plants.
تاريخ النشر
2018.
عدد الصفحات
ill. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
الناشر
تاريخ الإجازة
8/8/2018
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

The present study was interested with the phytochemical and biological
studies of some Egyptian medicinal plants as a source of natural products.
This study was done on four plants (Tamarix aphylla, Brassica nigra,
Thymelaea hrisuta and Euphorbia retusa).
The anti-inflammatory properties of all the extracts, fractions and pure
compounds separated from these plants were checked for their bioactive
products.
The present research work aims at:-
1- Screening the biological activities of the extract(s) and fraction(s) of
selected medicinal plants.
2- Isolation and purification of the compound(s) from the plant extracts
using chromatographic techniques.
3- Structure elucidation of isolated metabolites via spectroscopic
techniques.
4- Determination of the bioactive compound(s) using bioassay guided
isolation procedures.
The present thesis is divided into:
Chapter 1: Introduction
It is including a brief introduction about
XII
1- The importance of natural products in drug discovery.
2- Ethnopharmacology and potency of Egyptian medicinal plants.
3- Anti-inflammatory agents and inflammation.
4- Summary of literature survey done on the selected plants.
Chapter 2: Materials and methods
This section includes the following:
1- It describes the collection and identification of selected plants.
2- It describes the apparatus and methods used for extraction, isolation,
purification and identification of the isolated compounds.
3- It describes the methods followed in the immunomodulatory
activities (anti-inflammatory) examination of extracts and pure
compounds.
Chapter 3: Results and discussion
Phytochemical investigation of Tamarix aphylla aerial parts leads to
isolation of four compounds [3,5-Dihydroxy-7,4’-dimethoxyflavone(1);
Methyl 4-O-methylgallate(2); 3,4’,5,7-Tetrahydroxyflavone (3); and
Trans-3-Hydroxy-4-methoxycinnamic acid (4)]. The structures
elucidation has been carried out using X-ray, UV, IR, one and two
dimensional NMR, and high-resolution mass spectrometry followed by
comparison with spectroscopic data of closely related structures.