الفهرس 
Neonatal SepsisOnly 14 pages are availabe for public view
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Abstract
Neonatal sepsis is a serious invasive bacterial infection occurs during first 28 day of life which results in death or major disability for 39% of those affected even with timely antimicrobial treatment. Neonatal sepsis remains one of the leading causes of morbidity and mortality both among term and preterm infants. The incidence of neonatal sepsis varies from country to country, nursery to nursery and in the same nursery at different times. Diagnosis of neonatal infection still the greatest and most difficult challenge for a neonatologist as the clinical picture of neonatal sepsis is non-specific. Blood culture is still the gold standard for sepsis diagnosis but results are not immediately available and pathogens are only detected in approximately 25% of cases. Microvascular and endothelial dysfunction are key contributors to organ failure and death in sepsis. NO is one of the most potent vasodilators known, and is essential to maintain a quiescent and functional endothelium. ADMA is an endogenous NO synthase (NOS) inhibitor. The aim of our study was to determine the serum level of ADMA in newborn with sepsis and correlation between its level and severity of disease. This study was carried out at neonatal intensive care unit of Tanta University Hospital. This study was conducted on 60neonates. These neonates were divided into 2 groups; group (A): included 30 newborns were evaluated according to history, physical examination, clinical picture and laboratory investigations for possible causes of neonatal sepsis in neonatal intensive care unit. group (B): 30 healthy newborn as control group. In both group the following will be done: 1- Complete history taking. 2- Clinical examination. 3- Laboratory investigations: a- Complete blood counts with differential counts (CBC), include ratio of immature to total neutrophil. b- C- reactive protein (CRP). c- Urine analysis c- Blood culture. d- Lumbar puncture, if feasible. 4- Radiological investigation: X-ray chest 5- Specific investigation: Serum ADMA level will be measured by enzyme –linked immunosorbent assay (ELISA).