الفهرس 
Clinical Consideration
Laboratory considerationOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion
Multiple scelorasis(MS) is a chronic disease of the central
nervous system with disseminated inflammatory demyelinating lesions
and axonal loss leading to multifocal signs of neurological deficit.
Sleep disorders are pervasive in patients with MS although
clinically under recognised by most physicions .Sleep disturbances
reported by 24-50% of MS patients. Circadian rhythm disorders with
compromised melatonin secretion, reduced input to the suprachiasmatic
nucleus as well as increased level of proinflammatory cytokines have
been suggested as possible pathomechanisms shared by MS and sleep
disturbances .
The current study was a controlled one that was conducted on 40
subjects aged from 20 to 40 years old of both genders ,Patient group
Including 20 patients with newly diagnosed Multiple Sclerosis
according to the revised Mc Donald criteria 2010. With exclusion of
Medicated MS patients.
- Presence of any organic co-morbidity eg.(DM.hypertension)
-Presence of any psychatric co-morbidity eg.(depression, anxiety)
- Patients receive any drugs affecting sleep.
- Patients with work shift.
- Patients with past history of primery sleep disorders.
For MS patient, the following were done.
- Thorough history taking, medical, neurological and psychiatric
assessment.
- Magnetic resonance imaging (MRI) of the brain