الفهرس 
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Abstract
The poor oral bioavailability of tenoxicam might be due to its very slow dissolution. Therefore, one of the promising drug delivery technologies is self nano emulsifying drug delivery system (SNEDDS) which is novel lipid-based preparations believed to enhance the absorption of class II drugs by fastening the rate limiting dissolution step through the formation of a nanoemulsion using gastrointestinal motility which is capable of maintaining a poorly soluble drug in solution. The objective of this thesis was to formulate tenoxicam SNEDDS using ternary phase diagram with the most suitable components according to the solubility study, then the prepared formulation were evaluated for its performance. These investigations along with the obtained results can be summarized as follows:
1- New self-nanoemulsifying drug delivery system (SNEDDS) is a promising strategy for enhancing the dissolution rate as well as the oral bioavailability of tenoxicam.
2- Definite compositions can produce successful nanoemulsion as oil ratio shouldn`t exceed 30 %while surfactant must be present in the range of 20%-70% while formulae contained more than 70% co-surfactant are subjected to loss of solvent capacity.
3- For each formulations (F1, F13,F29) were optimized has lower oil content this lead to minimum viscosity which indicated the resulted nanoemulsion to be O/W type ,was help enhanced drug released.
4- In vivo pharmacodynamic studies showed that SNEDDS has improved the oral bioavailability of the drug which may be due to the collective mechanism of dispersion with larger surface area.
5- Aerosil 380 was chosen as an adsorbent material for converting the optimized liquid formulation.
6- Small particle size droplets help in better performance of SNEDDS.
7- F1 was chosen as an optimum formula which contained 30% oil, 60% surfactant and 10% co-surfactant based on in vitro dissolution study, droplet size analysis and the other previously discussed parameters.
8- The study demonstrated the potential of SNEDDS for increasing the solubility and delivery of a hydrophobic drug, such as tenoxicam taken in the present study, by oral route