الفهرس | Only 14 pages are availabe for public view |
Abstract BACKGROUND: Obesity, a worldwide public health problem, is associated with a number of polymorphisms of genes involved in its pathogenesis. Thus, this case-control study aimed to clarify the association between genetic variations within methylene tetrahydrofolate reductase (MTHFR) and ATP-binding cassette transporter A1 (ABCA1) genes and obesity in an Egyptian population of children and adolescents. METHODS: Anthropometric parameters along with lipid profile were measured, in addition to genotyping of MTHFR C677T and ABCA1 G656A polymorphisms using allelic discrimination assay in 51 obese and 30 normal weight age and sex matched child and adolescent. RESULTS: Compared to control, obese subjects showed a significant difference in the presence of C677T polymorphism, but not G656A. C677T polymorphism increased susceptibility to obesity under all genetic models while G656A polymorphism failed to show any association with the predisposition of developing obesity. SNP-SNP interaction showed that CT/AG carriers are at a higher risk to develop obesity compared to wild type carriers. CONCLUSION: MTHFR C677T polymorphism could contribute to the development of obesity while there is no association related ABCA1 G656A polymorphism with simple obesity among Egyptian children and adolescents. Joint effects of the two genes revealed that the carriers of the mutant alleles of both MTHFR and ABCA1 are at high risk to develop obesity. |