الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Diabetes Mellitus (DM) is a major cause of morbidity and mortality. Diabetic retinopathy (DR) is one of the most common and severe complications of DM and is also the leading cause of early blindness in adults. Thus, the early detection of DR is important for the preservation of useful visual acuity in later life.
OCT angiography is a new convenient and noninvasive method for evaluating the microvasculature of the retina.
The present study aimed to evaluate changes occurring with diabetic retinopathy both at the macula and the periphery using OCTA. The study included 30 eyes fitting our inclusion criteria and was selected from patients of both genders at different ages.
In this study, we used a qualitative analysis for grading of DMI in FA and OCTA images. We have also obtained quantitative measurements of the FAZ and correlated them with the BCVA of the patient. We were able to detect microaneurysms and retinal neovessels using OCTA.
In the present study, we demonstrated that in DR patients the mean horizontal diameter of the FAZ of the superficial capillary plexus was 782± 283.96 µ and that of the deep plexus was 1267.33 ± 356.04µ. The mean vertical diameter of FAZ in the superficial plexus was 690.07 ± 236.17µ and that of the deep plexus was 1029.60 ± 334.87µ. The mean maximum diameter was 909.13±308.06µ in the superficial plexus and 1377.03±380.22µ in the deep plexus. The mean FAZ area of the superficial capillary plexus was 0.52 ± 0.30 mm2 and that of the deep plexus was 1.12 ± 0.59mm2.
In this study we demonstrated that in both the superficial and deep capillary plexuses, the maximum FAZ diameter and the 90° to the maximum are both correlated with the BCVA, and there was a positive correlation between the duration of diabetes and the FAZ area in both the superficial and deep capillary plexuses, but it was statistically insignificant.
We also demonstrated that images from FA and OCTA of the superficial retinal capillary plexus showed good agreement (κ= 0.642) regarding grading of diabetic macular ischemia.
In the present study, we also demonstrated that there was positive correlation between the micoaneurysm count in both FA and the superficial capillary plexus in OCTA, and between FA and the deep plexus. We also demonstrated that the detection of microaneurysms by OCTA was significantly lower than by FA, as shown by quantitative measurements.