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Abstract Preterm birth (before 37 completed weeks of gestation) is a ‘major cause of [postnatal] death and a significant cause of long-term loss of human potential. There is a substantial long-term health impact from preterm birth due to increased risk both of death and of developing a wide range of chronic physical and neurological disabilities compared to full term births. Approximately 70% of neonatal deaths, 36% of infant deaths, and 25-50% of cases of long-term neurologic impairment in children can be attributed to preterm birth. The percentage of under-five years deaths from preterm birth complications is still high in Egypt and our country is ranked as 144 worst on the list of 162 countries with prematurity related deaths comprising about 28.5% of all under-5 years deaths in Egypt Therefore, this study aims to evaluate the effect of vaginal progesterone on uterine and fetal vessels by Doppler sonography among women in the second and third trimesters of pregnancy who were at risk of preterm labor. A prospective clinical study was conducted on 60 pregnant patient at risk of PTL, they received 400-mg vaginal pessaries daily until 36 completed weeks of pregnancy by an independent obstetrician after a while from the first Doppler flow assessment. All patients attended the Obstetrics and Gynecology outpatient clinic at Menoufia university hospital and El-Shohada Hospital, Menoufia governorate, Egypt, during the period from December 2016 to February 2018. All pregnant women who fulfill the eligibility criteria are subjected to: History taking: such as present, past, obstetric and menstrual history with emphasis on history of onset, history of medical disorders, history of previous preterm labor, mode of delivery and fetal outcome.…etc. |