الفهرس 
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Abstract
The thesis is divided into four main parts:-Part I. includes general introduction about allergic rhinitis. Part II.A. includes an introduction to azelastine.Part II.B. includes spectrofluorimetric method for determination of Azelastine HCl either in pure state or in pharmaceutical dosage forms and study the stability of azelastine under stress conditions according to ICH guidelines.Part II.C. includes two spectroscopic methods for quantification of azelastine in bulk powder as well as in pharmaceutical dosage forms. The first method was based on measuring the absorbance difference between acidic and basic solutions, whereas the second investigated method was based on measuring the absorbance of the binary complex formed between AZL and Eosin Y in acetate buffer solution (pH 3).Part II. D. includes stability indicating microemulsion liquid chromatographic method for separation of Azelastine HCl from its degradation products.Part III. includes an introduction to fluticasone and green microemulsion liquid chromatographic method for the simultaneous estimation of fluticasone propionate and azelastine HCl in the presence of their pharmaceutical dosage form additives (phenylethyl alcohol and benzalkonium chloride). Part IV.A. includes an introduction to budesonide. Part IV.B. includes spectrophotometric methods for determination of a novel combination of budesonide and azelastine according to the recommended ratio of 1: 4.28.Part IV.C. includes HPLC method for simultaneous determination of a novel combination of budesonide and azelastine. The separation of epimers of budesonide and azelastine was achieved with good performance in relatively shorter time, satisfactory resolution and good acceptable values of LOD, LOQ and % RSD according to the recommended ratio of 1: 4.28.