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Abstract The study was performed in Faculty of veterinary medicine; Alexandria university Biochemical department to detect the biochemical effect of Petroselinum crispum on streptozotocin induced diabetic albino rats. The study lasted for 30 days and was carried out on 40 albino rats of 150-180 gm body weight were divided into 4 groups (10 rats / group) group 1: control group This group contains 10 rats and kept on basal ration group 2: Parsley group This group contains 10 rats and kept on basal ration + Parsley 2gm/kg body weight group 3: Diabetic group This group contains 10 rats and kept on basal ration group 4: Diabetic + Parsley This group contains 10 rats and kept on basal ration + Parsley 2gm/kg body weight Blood samples collected from each group and centrifuged to get the serum to perform the following biochemical analysis: 1. Fasting blood glucose 2. Glycosylated hemoglobin 3. Fructosamine 4. Fasting insulin and HOMA 5. Liver function 6. Kidney function 7. Lipid profiles After collection of blood samples, animals slaughter to take liver washed with saline to determine the following parameters: 1. GSH 2. NO 3. MDA 4. Total antioxidant capacity The results and statistical analysis revealed the following: 1. Treatment of the STZ induced diabetic rats with parsley resulted in significant decrease in fasting blood glucose and Hba1c compared to control group but there is no significant difference within all groups in fructose amine 2. Treatment of the STZ induced diabetic rats with parsley has no significant difference within all groups in liver and kidney function 3. Treatment of the STZ induced diabetic rats with parsley has no significant difference within all groups in lipid profile 4. Treatment of the STZ induced diabetic rats with parsley resulted in significant increase in liver antioxidants. |