الفهرس 
Nonalcoholic Fatty Liver Disease and Nonalcoholic SteatohepatitisOnly 14 pages are availabe for public view
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Abstract
Background: non-alcoholic fatty liver disease (NAFLD) has become the most prevalent cause of liver disease. The development of nonalcoholic steatohepatitis (NASH) and fibrosis identifies an at-risk group with increased risk of liver-related deaths. The identification and management of this at-risk group remains a clinical challenge. Liver biopsy remains the gold standard for characterizing liver histology in patients with NAFLD. However, it is expensive and carries some morbidity and very rare mortality risk. Thus, it should be performed in those who would benefit the most from diagnostic, therapeutic guidance and prognostic perspectives.
Aim of the work: this study aimed to assess the diagnostic significance of human patatin like phospholipase domain containing protein 3, PNPLA3 versus fibro scan in nonalcoholic fatty liver disease (NAFLD).
Patients and Methods: this study was performed on 80 patients recruited from the Gastroenterology and Hepatology Unit of the Internal Medicine Department at Ain Shams University Hospital (Blood samples were collected from each subject & pnpla3 was measured using ELISA technique & then results were compared to Fibroscan results done for same subjects).
Results: this study was conducted on 40 patients with NAFLD who fulfilled the pre designed inclusion criteria and 40 individuals with normal liver attending Internal Medicine Department, Ain Shams University Hospital. (PNPLA3 was associated with increased ALT & AST levels, & also with the histologic severity of NAFLD severity regarding degree of steatosis & fibrosis).
Conclusion: our study expands on these observations by mounting evidence suggested that the PNPLA3 represent a determinant of hepatic steatosis and represented a useful tool to identify degree of steatosis and/or fibrosis, also identify CAP as a new tool to measure liver fat and by showing its value in the carriers of the PNPLA3.