الفهرس 
(I)-Colorectal Carcinoma (CRC)
Start and Spread of CRCOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer (CRC) is the third leading cause of cancer-related death in both man and woman in the world. It is estimated that up to 10% of CRC cases may be due to hereditary factors while the other of 90% of CRC cases may be attributed to various environmental and lifestyle factors such as dietary habits, obesity and physical inactivity. It was found that human colorectal mucosa has increased levels of different markers of oxidative stress (OS),such as increased levels of (ROS) which may play a role in development of CRC.Markers of protein oxidation named as advanced oxidation protein products(AOPPs).The concentrations of AOPPs increase with progression of diseases therefore,AOPPs have been considered as novel disease- related biomarkers for OS. Reactive oxygen species (ROS) may indeed interact with genomic DNA, causing DNA fragmentation. The formation of damaged DNA, either deriving from defective repair or increased oxidative damage,may therefore influence the process of carcinogenesis.