الفهرس 
NAFLDOnly 14 pages are availabe for public view
 |  | from | 127 |  |  |
| | | from | 127 | | |
Abstract
Background: Ghrelin, the ”hunger hormone”, is a peptide produced by gherlin cells in the gastrointestinal tract which functions as a neuropeptide in the central nervous system. Beyond regulating hunger, gherlin also plays a significant role in regulating the distribution and rate of use of energy. Aim of the work: To evaluate the level of gherlin hormone in Egyptian patients with NAFLD and its relation to severity of liver affection in such patients. Patients and methods: This study included 60 patients of them: 40 patients with NAFLD (group I) subdivided into: group l a) 20 patients with steatosis. group l b) 20 patients with NASH; and 20 patients without NAFLD (group II) as controls. Results: Conclusion: NAFLD is becoming a serious threat to public health worldwide. However, the underlying mechanisms leading to the development of NAFLD are not fully understood. The involvement of the ghrelin-GOAT system in NAFLD and a better understanding of its biology have led to the identification of pharmacologic targets and the development of pharmacologic compounds for the treatment of NAFLD and related diseases. Thus, the ghrelin-GOAT system represents a promising target for the treatment of NAFLD. Recommendation: The role of gherlin hormone in appetite regulation and energy metabolism is well –established and it is now recognized as a critical therapeutic agent against NAFLD.