الفهرس 
Chronic Kidney DiseaseOnly 14 pages are availabe for public view
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Abstract
Abstract
Background: Cardiovascular disease is the main cause of morbidity and mortality in dialysis patients. This is proposed to be associated with accelerated atherosclerosis. Increased carotid intima-media thickness (CIMT) is a subclinical atherosclerosis marker. Atherogenic index of plasma (AIP = log(TG/HDL-c)) recently started to gain attention as an easy non-invasive atherosclerosis marker in the general population.
Aim of the study: Our aim was to investigate the correlation between atherogenic index of plasma and carotid intima-media thickness as an indicator of subclinical atherosclerosis in haemodialysis patients.
Patients and Methods: A total of 60 persons with 40 patients under hemodialysis therapy and 20 healthy volunteers were included in the study. In all the participants, CIMT was measured using B-mode ultrasound with detection of plaques and AIP was calculated after performing fasting lipid profile and other routine laboratory tests. AIP and CIMT values of the participants were compared with blood pressures, lipid profiles and other cardiovascular risk factors.
Results: AIP (0.25 ± 0.20) and CIMT (1.16 ± 0.53) were found significantly higher in the patient group than in the controls (0.03 ± 0.10 and 0.53 ± 0.22, respectively); (P = 0.001 and 0.001, respectively). There was a significant correlation between AIP and increased CIMT in the patient group (P = 0.001, r = 0.662). Among the lipid parameters, the strongest correlation was found between CIMT and AIP. We demonstrated the significant increase of AIP and CIMT in hemodialysis patients. A correlation was found between AIP and CIMT. AIP was found to show a correlation with a greater number of cardiovascular risk factors than CIMT.
Conclusion: These data suggest that AIP may be a method which can be used in diagnosis of subclinical atherosclerosis in hemodialysis patients.