الفهرس 
General Properties of Stem CellsOnly 14 pages are availabe for public view
 |  | from | 151 |  |  |
| | | from | 151 | | |
Abstract
Umbilical cord blood is rich in hematopoietic stem /progenitor cells and can be used as an alternative source of stem cells for transplantation. A major advantage for umbilical cord blood as a stem cell source for allogeneic hematopoietic stem cell transplant is its immediate availability. Additionally, the native nature of its lymphocytes led to decreased risks of graft versus host disease and allowed for successful HLA mismatched transplant with low rates of acute and chronic graft versus host disease. This has resulted in umbilical cord blood being a widely used source for hematopoietic stem cell transplant to treat many malignant and non-malignant diseases. The aim of the study was to show the effect of maternal and neonatal factors on umbilical cord blood CD34+Cells. The present study was carried out on umbilical cord blood sample which was collected in delivery room in El-Mehalla general Hospital and sent to the Center of Excellence at Tanta University Internationl Educational Hospital. The study was done on 20 mothers during Labour, their ages ranged from 22 to 34 years, 19 women were delivering by CS and only one woman was delivering by noramal vaginal delivery , 9 women were delivering male infant and 11 women were delivering female infant All mothers were subjected to history taking concerning maternal age , gestation period , number of previous live births and knowing the route of delivery and their babies were subjected to clinical examination concerning Weight and sex of the baby. Laboratory investigation included assessment of number of CD34+ cells in collected umbilical cord blood. The results of this study tabulated and statically analyzed showing the following results: 1. Maternal age had no significant effect on CD34+ cells count. 2. Gestation period had no significant effect on CD34+ cells count. 3. There was significant effect of weight of the baby on CD34+ cells count with positive correlation as increase of baby weight leads to higher CD34+ cells count. 4. There was no significant effect of route of delivery effect on CD34+ cells count. 5. There was no significant effect of sex of the baby effect on CD34+ cells count. 6. Number of previous live births had significant effect on CD34+ cells count with the first baby having higher CD34+ cells count than the second and the second more than the third and the third more than subsquent births.