الفهرس 
Diabetes mellitusOnly 14 pages are availabe for public view
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Abstract
DM is a group of metabolic diseases in which a person has high blood glucose, either because the pancreas does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood
sugar produces the classical symptoms of polyuria,polydipsia and polyphagia.At 2016 it has been estimated that number of diabetic patients was 415 million people. Its incidence is increasing rapidly, and by 2040, this number is estimated reach 642 million.SIRT1 modulates FOXP3 and thereby influences Treg cell development, which is essential for the maintenance of immune homeostasis and protection against autoimmunity.SIRT1 plays an important role in nutrient-sensing and insulinsignaling pathways, as well as in the regulation of stress responses that determine cell survival, apoptosis, and proliferation. The risk C allele has been associated with impaired insulin secretion and insulin processing,subsequently resulting in hyperglycemia.Polymorphisms in SIRT1 lead to expression of SIRT1-L107P in insulin-producing cells which result in overproduction of nitric oxide,cytokines, and chemokines. SIRT1 deficiency impairs mTORC2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.The aim of this study was to evaluate the association between the mammalian silent information regulator two1 gene (SIRT1) polymorphism and the development of diabetes mellitus.