الفهرس | Only 14 pages are availabe for public view |
Abstract Summary This study aimed to assess seminal Beclin-1 in infertile men with varicocele.Eighty nine men were included after institutional approval and informed consent. They were divided into; Fertile normozoospermic men (n=16) Infertile OAT men without varicocele (n=23) Infertile OAT men with varicocele(n=50). Inclusion criteria: Normal female factor and OAT. Exclusion criteria: Azoospermia, subclinical Vx, smoking, leukocytospermia and congenital anomalies. They were subjected to: History taking. Clinical examination. Semen analysis(WHO, 2010). Varicocele cases underwent varicocelectomy and were followed up for 3 months post-operatively. Seminalplasma Beclin-1was estimated by Western blot method. The results demonstrated the following: Seminal Beclin-1 expression demonstrated significant decreases in infertile OAT with/without varicocele compared with fertile men. Seminal Beclin-1 expression demonstrated significant decreases in infertile OAT with varicocele compared with infertile OAT men without varicocele. Seminal Beclin-1 expression demonstrated significant increases in infertile OAT with varicocele after varicocele repair compared with their pre-operative data. Seminal Beclin-1 expression demonstrated significant decreases in infertile OAT men with grade III varicocele compared with infertile OAT men with varicocele grades I and II. Seminal Beclin-1 expression showed significant positive correlation with sperm concentration, sperm motility, sperm normal forms percentages and nonsignificant correlation with the age. Conclusions Seminal Beclin-1 expression has a role of male infertility being significantly decreased in infertile men in general and in infertile men associated with varicocele in specific. Seminal Beclin-1 expression is increased after surgical repair of varicocele associated with improved sperm concentration, sperm motility as well as sperm normal forms. |