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العنوان
Development of electroanalytical methods for trace determination of some biologically active compounds using different types of electrodes /
المؤلف
El-Fiky, Mona Nabil Kamal.
هيئة الاعداد
باحث / منى نبيل كمال الفقى
مشرف / اميرة محمود حسانين
مناقش / نهال عاطف صلاح الدين
مشرف / لا يوجد
الموضوع
Chemistry.
تاريخ النشر
2018.
عدد الصفحات
p 181. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Analytical Chemistry
تاريخ الإجازة
14/8/2018
مكان الإجازة
جامعة طنطا - كلية العلوم * - Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 239

Abstract

Nanotechnology has shown a great potential in different applications that widely used in our life one of these applications is the bio-sensors that have high sensitivity. Solid electrodes based on carbon are currently in wide spread use in electroanalysis because of their broad potential window, low background current, rich surface chemistry, low cost, and chemical inertness. However, their sensitivity is relatively poor towards the determination of some biologically active compounds and metal ions. This may be attributed to its high surface hydrophobicity, which is mainly responsible for high overpotential (irreversibility) and sluggishness of the kinetics of the electrode process, resulting in weak electrochemical responses. A fascinating and effective way to improve the sensitivity is to find a good modifier to increase the rate of electron transfer (on one side), surface area and consequently the adsorptive affinity of the surface of carbon electrodes (on other side). Nanotechnology has shown great potential in different applications that widely used in our life one of these applications is the bio-sensors that have high sensitivity. The work in this Thesis aimed to prepare different types of bio-sensors and elucidate the electrode reaction pathways of some biologically active compounds (Isoxsuprine HCl (IS.HCl), Terazosin HCl (TRZ.HCl) and Ofloxacin (OFX)) in buffered solutions of various pH values, and identification of their adsorptive behavior at the unmodified carbon paste electrode (Bare CPE) or that modified with different types of nanocomposites or Different carbon materials. The modifiers used in this work are Chitosan-ZnO/Polypyrrole, Layered Double Hydroxide/ Polypyrrole nanocomposites and Crystalline Flake Graphite/Multiwall nanotubes Carbon.