الفهرس 
Diabetes mellitusOnly 14 pages are availabe for public view
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Abstract
In this study, we aimed to determine urinary Transferrin in patients with type2 diabetes as a marker for diabetic nephropathy.
This study was conducted on 60 patients (40 diabetic and 20 non diabetic patients) and 20 healthy individuals. Patients were selected from out patients and in patient clinics of Internal Medicine Department, Minoufia University Hospital-Egypt during the period from Jan, 2017 to May, 2017. Informed consent was obtained from all participants who were be fully informed about the study according to ethical medical committee of Menoufia University Hospital.
Subjects were divided into 4 groups:
group 1) 20 type 2 diabetic patients with proteinuria.
group 2) 20 type 2 diabetic patients, but without proteinuria.
group 3) 20 non-diabetic patients with CKD and proteinuria.
Group4) 20 healthy subjects as a control group.
Exclusion criteria: Patients with chronic liver disease, chronic heart failure, urinary tract infection, body mass index > 30 kg/m2 and recent infection.
All subjects were subjected to the followings:
•Full history taking.
•Complete clinical examination and measurement of body mass index.
Investigations :-
Routin investigations:
1.Complete urine analysis.
2.C.B.C.
3.Blood glucose level (fasting, 2hours post prandial) and HbA1c.
4.Plasma lipid profile ( T.cholestrol& T.Gs)
5.The liver function test (SGOT,SPOT,P.T, Serum albumin, T.s. bilirubin)
6.Renal function test (urea and creatinine).
7.Glomerular filtration rate (GFR) :estimated by MDRD
8.Urinary albumin/creatinine ratio
9.Abdominal ultrasonography for kidney, liver, spleen and presence orabsence of ascites.
Special investigations:
- Measurement of urinary Transferrin by Eliza.
Results showed:
- significant Increase in urinary Transferrin excretion in DM with proteinuria than other patients and controls.
- significant High lipid profile (cholesterol, TGs) levels with DM and CKD patients in comparison to the control group, and in DM with proteinuria group than other groups.
- significant Increase in serum urea and creatinine and urinary Alb /creat ratio and decreased eGFR in DM with proteinuria patients compared to DM without proteinuria group.
- Positive non-significant correlation between (urea creatinine and urinary Alb/creat ratio) and urinary Transferrin in DM with proteinuria.
- Positive non-significant correlation between urinary Transferrin excretion and cholesterol, triglycerides levels in DM with protinuria and -ve non-significant correlation in DM without proteinuria and CKD.