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Abstract SUMMARY AND CONCLUSIONS Trichinellosis is a huge food-borne parasitic zoonotic disease caused by eating undercooked or raw meat harboring the infective Trichinella larvae. It infects many mammalian, avian and reptile host species in which the adult worms and the larvae reside in the small intestinal and muscle tissues, respectively. Human trichinellosis has been documented in 55 countries in the world. Trichinellosis is an emerging and re-emerging zoonotic disease with health, economic and social impacts in developing countries. The clinical diagnosis of trichinellosis is hard as the clinical symptoms are nonspecific. Trichinella infection in the human host can be divided into two phases: an intestinal (or enteral) phase and a muscular (or parenteral) phase. Infections with low intensities can remain asymptomatic, but infection with more than a few hundred larvae results in gastroenteritis in the form of abdominal pain and diarrhea about 2 days P.I. (intestinal acute phase of disease). Migrating Trichinella larvae and their metabolites provoke an immediate reaction, resulting in pathological, immunological and metabolic disturbances and the various clinical phenomena observed during the acute stage of the infection. The immunological reaction is characterized by infiltrating inflammatory cells (i.e., mast cells, eosinophils, monocytes and lymphocytes). The severity of clinical disease in T. spiralis depends on the number of infective larvae ingested by the patient. Thus, infection may result in various clinical forms ranging from asymptomatic to. |