الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 119 |  |  |
| | | from | 119 | | |
Abstract
Background/Aims: To evaluate peripheral insulin resistance IR and prevalence of diabetes mellitus in patients of chronic hepatitis C that are relapsers before treatment and after 12 weeks of treatment with direct oral antiviral drugs DAA
Methods: Fifty patients with chronic hepatitis C that are non-responder to treatment before were enrolled in this study and classified into two groups: treated by direct oral antiviral drugs DAA failed to achieve SVR at 12 weeks (n=25) and the other group who achieved SVR at 12 weeks (n=25). All subjects were evaluated at the beginning of the study and 6 months later. PCR quantitave for all patients with chronic hepatitis C. Insulin resistance was calculated through the HOMA method as follows:
HOMA = fasting serum insulin (µu/ml) X serum glucose (mmol/dL) / 22.5.
Patients were categorized as insulin resistant if HOMA was greater than 2 and diabetes if greater than 4. Also body mass index (BMI) and waist circumference were calculated.
Results: In chronic hepatitis C with failure on retreatment HOMA-IR showed highly significant increase (P=0.001). from 5 cases (20%) become 11 cases (44%), 5 cases of them (20%) developed DM, but in patients of chronic hepatitis C who achieved SVR at 12 weeks, 12 cases of insulin resistance pretreatment and after 6 months were as follows:
3 cases became non-insulin resistant and
2 case became insulin resistant and
2 cases developed DM and
5 cases had no changes (still insulin resistant).
Other 13 cases who were non-insulin resistant pretreatment and after 6 months were still the same and HOMA IR decreased significantly after therapy (P<0.01)
Conclusions: After 6 months of treatment we found there is highly decrease in insulin resistance in patients after eradication of HCV and highly increase insulin resistance in non responder patients.