الفهرس 
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Abstract
This study was conducted to evaluate clinically and histologically the bone regeneration potential when using N2Butylcyaniacrylate tissue adhesive in the fixation of dentoalveolar fracture defect compared to a fracture defect that fixed with conventional cercumdental wiring.
Six healthy mongrel dogs were used in this study, dogs kept in the animal house at the physiology department Faculty of Medicine University of Alexandria. Dogs were kept under the same nutrition and environment throughout the whole period of study. All dogs were examined by a veterenian.
Operation procedure were performed under general anesthesia and a strict sterile general antiseptic conditions.
A fracture bone defects were created on the alveolar bone at the mandibular premolar area in a vertical direction, using a surgical bure with water cooling system.
The right sides of the mandibles were the study group fixed with N2BCA, were as the left sides were the control group fixed with a conventional cercumedental wiring. Each dog was a member of the two groups all animal received the same course of antibiotics and analgesics for 5 days postoperatively. Dogs were observed daily in the first week by a veteranian to assess signs of inflammation or wound dehiscence after surgery.
Dogs were sacrificed by an overdose of thyopentone sodium on the 6th, 9th, 12th week, 2 dogs at each intervals.
Specimens were harvested and fixed in 10% formalin for 15 hours.
Demineralization of the bone embedded into paraffin wax qand stained with Hematoxillin and Eosin and Trichrom stains for histological evaluation of the granulation tissue formation, woven bone and lamellar bone formation.
Results showed that no significance different between the two materials in osteococductuity and osteointegration. This study support the use of N2BCA adhesive as an alternative to the conventional means of fixation.