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العنوان
Efficient Microwave-Assisted Solvent-Free Synthesis of 2-pyridone Derivatives as anticancer agents and Evaluation of Cytotoxic Effects /
المؤلف
Abdellattif, Magda Hassan Moustafa.
هيئة الاعداد
باحث / ماجدة حسن مصطفى عبد اللطيف
مشرف / عادل عبد الهادي نصار
مشرف / عبد العليم حسن عبد العليم
مشرف / محمد حلمي عريف
الموضوع
Chemistry, Organic. Pyridone.
تاريخ النشر
2018.
عدد الصفحات
122 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
24/4/2018
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Development of biologically active anticancer drugs with low toxicity is the essential targets of the current research. Several 2-pyridones analogues are well-known important as cancer chemotherapeutic. A green protocol will be used to synthesize a novel series of 2-pyridone analogues in solvent-free medium using microwave irradiation as fast, economic and efficient method. Conventional methods will be used to synthesize the novel derivatives. Structures of the new products will be confirmed on the basis of spectroscopic data (FT-IR, 1D, 2D-NMR, and GC-Ms) as well as alternative synthetic routes. Absorption and emission properties as well as photochemical behavior of the novel 2-pyridones as heterocyclic will be deeply investigated.