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العنوان
Intra Ocular Tension Changes In Steroid Responders & Non-Responders After Triamcinole Acetonide Inravitreal Injection /
المؤلف
El-Shafie,, Ahmed Yousry.
هيئة الاعداد
باحث / أحمد يسري الشافعي
مشرف / حسام الدين محمد خليل
مشرف / وليد محمد مهران
الموضوع
Eye Diseases. Intraocular pressure. Steroids.
تاريخ النشر
2010.
عدد الصفحات
67 Leaves :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب العيون
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة بني سويف - كلية الطب - طب وجراحة العيون
الفهرس
Only 14 pages are availabe for public view

from 77

from 77

Abstract

SUMMARY
Steroids are a class of medications being studied with intense interest for the treatment of diabetic macular edema. They are known to be effective for the treatment of inflammatory types of macular edema, such as uveitis or pseudophakic CME.
The use of corticosteroids to treat ocular inflammation is an established method dating back to the 1950s. Topical application is sufficient for the anterior segment but does not deliver adequate drug levels to the vitreous and retina.
Subtenon and retrobulbar routes are used routinely for the administration of steroids to the posterior segment, but the need to diffuse across the sclera and the vascular bed in the choroid coupled with the highly variable rate of steroid dissolution from crystals make intraocular steroid levels variable and difficult to assess and to adjust.
Previous studies have shown that one of the most common side effects of intravitreal triamcinolone acetonide was a steroid-induced elevation of IOP.
We did this study to evaluate IOP changes after intravitreal injection of triamcinolone acetonide 4mg in treatment of macular edema. And also to evaluate how often and when IOP rises after the injection of triamcinolone acetonide intravitreally.
Dividing cases into two groups helped us to evaluate the value of administration of topical steroid as a provocative test before intravitreal injection of triamcinolone acetonide.
According to our results, we found that the IOP were elevated in 25% of eyes > 20 mmHg in which topical antiglaucoma medications was enough for treatment of most of cases with triamcinolone-induced rise in the IOP.
The study showed that the administration of topical steroid as a provocative test can not help predicting the possibility of IOP elevation after intravitreal Triamcinolone acetonide injection.
We discover in our study that young age more liable to develop high IOP following intravitreal injection of TA it was statistically significant (p=0.0002). But gender didn’t statistically affect the incidence of glaucoma significantly (p=0.1078).
We end by this study that we can take the advantage of intravitreal injection of triamcinolone in treatment of various diseases but close follow up of the IOP should be done and patients with Glaucoma better to be excluded.