الفهرس | Only 14 pages are availabe for public view |
Abstract A total of thirty apparently healthy New Zealand white mature rabbits each weighing between 2 and 2.5 kg were included in this study (Twenty females for the experimental work and ten male for preparation of stem cells). Two identical one cm full-thicknesses, circular wounds were created down to the cartilage on the ventral surface of each ear pinna under complete aseptic condition. The right ear was used as a control whiles the left one for the treatment. Two groups (each group contains 10 rabbits) were used as following: 1. group A: BMD-MSC (Bone Marrow derived – Mesenchymal stem cells) was injected into the wound bed. 2. group B: Corticosteroids (Triamcinolone acetonide) was injected into the wound bed. Stem cells and corticosteroids (TAC) used to inhibit the growth level of hypertrophic scar .The group injected with MSCs showed down-regulation of MMP-9, IL-6 and IL-1β genes lower than those injected with TAC. Also the present study observed up-regulation of TGF-β1, TGF-β2 and TIMP-1 genes of MSCs-treated group higher than TAC-treated one. Vascular endothelial growth factor (VEGF) plays an important role in wound healing through its pro-angiogenic ability and reduction of scar formation. Here in, we examined. |