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Abstract Breast cancer is the most common malignancy and the second leading cause of cancer deaths amongst women. Mastectomy with different techniques is still the main approach for cure especially in advanced cases, leaving women without breasts has disastrous psychological impact on them, so the need for breast reconstruction appeared either with implant-based and autologous tissue reconstruction, but the need for neoadjuvant or adjuvant radiation therapy is still a drawback for conducting breast reconstruction. Methodology: The data was extracted from PubMed and Cochrane collaboration data base and analyzed for assessment of the outcomes measured in this study. Results: The review included 9 studies reviewed for extracting the data on development of early and late, minor and major, and reconstruction failure rate in radiated breast reconstructed cases. Conclusion: Conducting IBR either with autologous or Implant-based reconstruction still carries higher rates of complication when compared to delayed one in radiated breast reconstructed patients |