الفهرس 
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Abstract
AD is a devastating and progressive neurodegenerative disease affecting approximately 5.3 million people in the United States, including almost half of the population at 85 years and older. AD is the fifth leading cause of death among older adults, and about 200 billion dollars are spent annually on direct care of individuals living with dementia.
AD is caused by a combination of genetic, lifestyle, and environmental factors with exact causative factors just beginning to be understood.
Apolipoprotein E (Apo E) has greatest impact on the risk of developing late-onset AD. APOE has three isoform E2-E3-E4. Everyone inherts one of three forms of Apo E gene from each parent. The E4 allele of the Apo E gene indicates a predisposition to earlier onset of AD.
It has been reported that heterozygotes for the E4 allele are three to four times as likely to develop AD as non-carriers, and the number of copies (one or two alleles) of E4 carried is proportional to level of risk. The number of E4 copies carried is significantly associated with disease manifestation age, with E4/E4 carriers showing the earliest disease onset.
The aim of this study is to assess the relationship between Apo lipoprotein E polymorphism and AD in Egyptian patients.
In this study we investigated 30 AD patients their age ranged from 40 to 70 years old, 19 males and 11 females, in addition to 30 healthy controls their age ranged from 40 to 70 years old and they were 20males and10 females.
All patients were submitted to the following :Full history taking including DM, hypertension, smoking, history of memory problem, family history and routine laboratory investigations including: Fasting blood sugar, TSH lipid profile(total cholesterol, TG,LDL,HDL) and APO E gene polymorphism analysis by real time PCR.