الفهرس 
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Abstract
Pre-eclampsia is a syndrome diagnosed by hypertension and proteinuria after 20 weeks of gestation, affects 5–10% of all pregnancies and remains a leading cause of maternal and fetal morbidity and mortality. Based on clinical presentation, pre-eclampsia is considered as a late pregnancy disorder, but the molecular events leading to its onset seem to occur early in pregnancy. Maternal symptoms of preeclampsia are considered consequences of placental pathology associated with poor placental perfusion, inflammation and ischemia / hypoxia and trophoblast damage.
This work was designed to study the serum level of CA 125 in preeclamptic and normotensive pregnant women at third trimester and to correlate level of CA125 with severity of pre-eclampsia.
The patients were recruited from El-Shatby Maternity University Hospital. They were divided into three groups, group (Ï): twenty normal pregnant women, group (ÏÏ): twenty mild preeclamptic patients and group (ÏÏÏ): twenty severe preeclamptic patients.
All patients (n=60) underwent complete history taking, clinical examination, ultrasound examination for fetal biometry, mean gestational age, amount of liquor and Doppler US.
Laboratory investigations were carried out including complete blood count, liver function tests, renal function tests, and complete urine analysis with albumin in urine and serum level of maternal CA125.
The results showed that there was no statistical significant difference as regards age, BMI, gestational age and gravidity& parity.