الفهرس 
Nonalcoholic Fatty Liver DiseaseOnly 14 pages are availabe for public view
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Abstract
Nonalcoholic fatty liver disease (NAFLD) has become one of the most common causes of chronic liver diseases worldwide. Previous studies found an association between hyperuricemia and fibrosis stages in NAFLD, presumably due to the antioxidative property of uric acid, even though the results were inconsistent across different studies. Because serum urate increases with age, postmenopausal women tend to have higher serum uric acid levels than premenopansal women. It has therefore been attractive to hypothesize that changes occurring at the menopause are the cause of this relative hyperuricemia. So, the present study aimed to assess the association between serum uric acid and NAFLD in pre- and postmenopausal women. The study recruited 40 women classified into 4 groups: group I that included 10 normal premenopausal women under 40 years old; group II that included 10 normal postmenopausal women above 45 years old; group III that included 10 premenopausal women with steatosis under 40 years old and group IV that included 10 postmenopausal women with steatosis above 45 years old. All participants were subjected to careful history taking, thorough clinical examination and laboratory investigations including serum uric acid, serum E2, lipid profile and renal and kidney functions. In the current study, it was found that patients in GIII and GIV had significantly higher BMI when compared with GI and GII patients. Regarding blood glucose levels, the studied patients in the current study revealed significantly higher FBG and PPBG when compared with controls. In addition, it was shown that postmenopausal women had significantly higher FBG and PPBG when compared with premenopausal women (GII vs GI and GIV vs GIII respectively). In respect to liver enzymes, our study showed that patients with steatosis (GIII and GIV) had significantly higher ALT and AST levels when compared with patients without steatosis (GI and GII). Considering lipid profile, we found that patients with steatosis (GIII and GIV) had significantly higher total cholesterol, triglycerides and LDL levels when compared with patients without steatosis (GI and GII). In addition, it was found that HDL was significantly lower than patients with GIII and GIV when compared with patients in GI and GII. As expected, the current study found significantly higher E2 levels in premenopausal women (GI and GIII) when compared with postmenopausal women (GII and GIV). This is a physiological finding. Importantly, our study found significantly higher serum uric levels in patients with steatosis (GIII and GIV) when compared with patients without steatosis (GI and GII). Also, it was found that postmenopausal women (GII and GIV) had significantly higher serum uric acid levels when compared with premenopausal women (GI and GIII) respectively. Correlation analysis showed that serum uric acid levels in the studied patients was significantly associated with patients age. In addition, it was noted that there is a direct significant between serum uric acid and fasting blood glucose. Moreover, we noted significant correlation between total cholesterol levels and HDL levels and serum uric acid. Remarkably, the present study found a significant inverse correlation between serum uric acid in the studied patients serum E2 levels.