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العنوان
Renewable Materials as Precursors for the Synthesis of Biologically Relevant Heterocycles /
المؤلف
Aboelsoud, Fatma Ahmed Ahmed Ali.
هيئة الاعداد
باحث / فاطمة أحمد أحمد علي أبوالسعود
مشرف / كمال يوسف صادق
مشرف / علاء عرفات حيالله
مشرف / عفاف محمد عبدالحميد
الموضوع
Asymmetric synthesis.
تاريخ النشر
2018.
عدد الصفحات
97 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة المنيا - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

We have developed an efficient synthesis of 6-amino-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles 69 via a four component reaction of aromatic aldehydes 26, malononitrile 38, hydrazine hydrate 14 and ethyl acetoacetate 35 and 2-amino-3-cyano-4-aryl-5-oxo-7,7-dimethyl-5,6,7,8-tetrahydrobenzo[b]pyrans 71 via a three component reaction of aromatic aldehydes 26, malononitrile 38 and dimedone 39c using glycerol as both solvent and catalyst at ambient temperature. This method is of several advantages such as green nature of high Eco Scale, atom economy and can be utilized for the synthesis of a large variety of essential polyfunctionally substituted Heterocycles.