الفهرس 
EPIDEMIOLOGYOnly 14 pages are availabe for public view
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Abstract
P
rimary malignant brain tumors are the 17th most common cancer type worldwide, with more than 250 000 new cases diagnosed annualy and approximately 77% of these are gliomas which can occur any where in the central nervous system but primarily occur in the brain and arise in the glial tissue.
Gliomas can be WHO grades I–IV based on malignant behavior. The most commonly occurring histologic types of gliomas in adults include astrocytoma (grades I–IV), oligodendroglioma (grades II–III), and oligoastrocytoma (grades II–III). Glioblastoma (WHO grade IV), the most common glioma in adults, accounts for 67% of all adult glioma diagnoses.
Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12–15 months for glioblastomas and 2–5 years for anaplastic gliomas.Also glioma varies with histopathology, patient age, gender, ethnicity, and geography. As a general rule, gliomas are more common in patients of older age, male gender, and Caucasian race.
This study is a retrospective analysis carried out in clinical Oncology and Nuclear Medicine department, Faculty of medicine, Ain Shams University between the period of 1st January 2012 till December 31 2016, where 152 medical records were analyzed, to assess the clinico-pathological features of Glial tumor patients.
All 152 eligible patients fulfilling the inclusion criteria and the medical sheets were reviewed including history, clinical and neurological examination, routine laboratory tests, radiological investigations, radiation therapy and follow up.
Several prognostic factors were analyzed in our study including age, sex, performance status, tumor size, site, grade, extent of surgery and type of treatment as regard chemotherapy and radiotherapy.
The age of patients ranged from 19-75 years with mean age of 48.42 ± 14.34 years. 65.8% of patients were male. 48% of patients had grade 1 in performance status at presentation. The most common presenting symptoms were those of increased intracranial tension as headache, blurring of vision amd vomiting followed by motor weakness.
The predominant site for gliomas was the temproparietal lobe followed by frontal lobe being more common on left side. 94% of the patients underwent pathological confirmation either by biopsy (stereotactic or excisional) or by surgical removal.
In this study 55.9% of gliomas were GBM being the most common rather than the other types.
About 78.3% of the patients underwent surgery with 16.4% of them underwent total excision while 18.4% underwent debulking.
The median PFS was found to be 14 months and the median OS of 17 months.
In our study we found a significant correlation between age, PS, pathological type and grade of the tumor and the treatment modalities such as surgery, chemotherapy (either concurrent or adjuvant) and radiotherapy with the overall survival.
Also there were prognostic factors affecting the PFS such as the PS and treatment specially radiotherapy but others failed to show a significant correlation with the PFS in our study.