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Abstract Congenital adrenal hyperplasia (CAH) is one of the most frequent congenital endocrine disorders; it comprises autosomal recessive disorders of cortisol biosynthesis in the adrenal gland caused by various enzyme deficiencies. The consequent compensatory rise of ACTH production causes hyperplastic growth of the adrenal glands. Treatment of CAH aims to reduce excessive androgen secretion by replacing the deficient hormones, where proper treatment with GCs and MCs prevents adrenal crisis and virilization, allowing normal growth and development. This study aimed to assess echocardiographic functions in children with congenital adrenal hyperplasia receiving corticosteroid therapy for a time interval ranging from 4 to 6 years. The present study has been conducted on twenty patients with congenital adrenal hyperplasia following up at the Paediatric Endocrinology Clinic of Ain-Shams University Hospitals. Patients were subjected to a detailed history taking and examination, anthropometric evaluation, Tanner staging, hormonal assay for androgen profile, Karyotyping, molecular study and echocardiographic examination. |