الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Migraine pathophysiology occupies a great area of contemporary research. Several studies have investigated the vestibular evoked myogenic potentials in migraine patients to characterize possible abnormalities. Higher rates of abnormal VEMP responses have been reported in migraine patients relative to normal subjects.
The aim of this study was to study cVEMP and oVEMP findings in migraine patients with and without vestibular symptoms.
The study was conducted on 30 adult subjects divided into three groups with no age or gender limit. The first group consisted of 10 healthy adult volunteers’ age and sex matched without any otological complaints. The second group included 10 migraine patients without vestibular symptoms, while the third group consists of 10 migraine associated vertigo patients.
History taking, peripheral hearing assessment besides to air conducted cervical and ocular VEMPs were performed to all included subjects attending in the Audio-Vestibular Medicine Unit, Alexandria University.
The parameters for cVEMP and oVEMP that were analyzed included Morphology of waveform, Latency, Amplitude and interaural difference.
Cervical VEMP could be recorded successfully in 100% of ears in the three studied groups. oVEMP could be recorded in all ears except for one in MAV patient. Moreover, we found abnormally delayed cVEMP P13 latencies in the migraine groups and abnormally increased inter-aural P13 latency difference in MAV group. cVEMP was more affected than oVEMP in migraine and VM patients.
The prolongation of cVEMP P13 latency indicates the central vestibular affection in migraineurs due to the abnormal neurotransmitter modulation originating in the brainstem. Our results indicate that migraine and migrainous vertigo patients might have lesion in both descending and ascending pathway interictally.
Even the sophisticated method as VEMP does not give the ultimate result confirming the vestibular migraine diagnosis, and neither do other diagnostic methods. VEMP results can contribute to the completion of full mosaic of migraine and vestibular migraine diagnosis.