الفهرس 
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Abstract
This study was performed at Faculty of Veterinary Medicine, Kafrelsheikh University, in the period from 2016 to 2017. It was aimed to study the negative effect of chronic heat stress (HS) on chicken growth, immune response, antioxidant activity and mRNA expression of nutrient transporter in the jejunum. Additionally, it was aimed to study the alleviating effect of GABA supplement on the previous HS adverse effects. Also, monitoring the effect of thyroid and antithyroid drugs on combating the negative effects of HS in broiler chicken. A total of 104 one day old male broiler chicken were used. At 25day old, birds were divided into equal eight groups, (n= 13 bird). Four groups were reared at normal ambient temperature (22 ± 2 °C) which were CN, GN, AN & TN. The other four groups were reared at high temperature (33±10c) which were CH, GH, AH& TH. At the end, blood samples, liver and intestine specimen were taken. HS decreased body weight, Ab titer and increased intestinal mucosa damage and gene expression of nutrient transporter. GABA significantly counteracted the negative effect of HS. PTU and thyroid drugs supplementations exaggerated the negative effect of HS.