الفهرس 
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Abstract
LPS directly causes liver injury by certain mechanisms involving activation of inflammatory cells such as Kupffer cells and macrophages. It also stimulates the releasing of chemical mediators such as superoxide, nitric oxide, tumor necrosis factor-α, IL6, IL4, IL10 and other cytokines. LPS induced the elevation in lipid peroxidation which is an index of oxidative stress.D.galactoseamine is another hepatotoxic agent and it increases the lethal effect of LPS.As a result, plant extracts of Ginger and Wheat germ Oil were used, as they have antioxidant properties .Eighty five male white albino rats, weighing 100 ±120 g were used. They divided into 4 groups each one, 25 rats except group one 5 rats and group four 30 rats: group 1control group. group 2 : Rats were pretreated by ginger extract for two weeks then injected with a single dose of LPS/DGa1N (0.233 mg/kg, 583.3 mg /kg) then sacrificed at 6,12,24 and 48 hours after induction except five rats were post-treated by ginger extract for another two weeks. group 3 : Rats were pretreated by W.G.O extract for two weeks then injected with LPS/DGa1N then sacrificed at 6,12,24 and 48 hours after induction except five rats were post-treated by W.G.O for another two weeks. group 4 : Rats were injected with LPS/DGa1N then sacrificed at 6,12,24 and 48 hours after induction except ten rats were divided into two subgroups. One of was post-treated by ginger extracts and the other post-treated with W.G.O, separately for another two weeks. The results reported that plant extracts Ginger or W.G.O could exert somewhere the same beneficial effects in tissue damage and reduce oxidative stress induced by LPS/DGa1N. Also, studies reported that pre and post treatment with these extracts were more beneficial than post treatment only.