الفهرس 
LOW-DOSE ACETYLSALICYLIC ACIDOnly 14 pages are availabe for public view
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Abstract
Background: Acetylsalicylic acid was synthesized in 1897. The product was called aspirin. In 1971, Vane described the mechanism of action of aspirin, showing that it inhibits the enzyme cyclooxygenase, thus avoiding prostaglandin (PG) synthesis. Aspirin (acetylsalicylic acid) is well known to have analgesic, anti-inflammatory and antipyretic properties. Since aspirin has been shown to increase uterine perfusion, it was not unreasonable to assume that aspirin administration may increase endometrial receptivity and blastocyst implantation.
Aim of the work: was to assess the efficacy of low dose aspirin treatment in increasing the clinical pregnancy in infertile women undergoing IVF /ICSI.
Patients and methods: The study included 200 infertile women undergoing IVF/ICSI who recruited from the infertility clinic of Ain-Shams University Maternity Hospital and a private center.
Results: There was no statistically significant difference between both groups (Asprin and Placebo) as regard (Age, Cumulus, MII, Fertilization rate, Grade 1 embryo, Grade 2 embryo and total ET). There was statistically non-significant difference between both groups as regard clinical pregnancy. There was statistically non-significant difference between both groups as regard living birth. There was statistically non-significant difference between both groups as regard miscarriage.
Conclusion: In the total of 200 women were recruited. The clinical pregnancy rate of the Asprin group showed no statistically significant difference from that of the placebo group (39% compared with 35%).
Recommendations: The use of Asprin before IVF is not associated with a higher pregnancy rate. Therefore, no need for Asprin to be added before IVF, However, further studies are needed to confirm our study.