الفهرس 
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Abstract
Pre-eclampsia is a syndrome diagnosed by hypertension and proteinuria after 20 weeks of gestation, affects 5–10% of all pregnancies and remains a leading cause of maternal and fetal morbidity and mortality. Based on clinical presentation, pre-eclampsia is considered as a late pregnancy disorder, but the molecular events leading to its onset seem to occur early in pregnancy. Maternal symptoms of preeclampsia are considered to be consequences of placental pathology associated with poor placental perfusion, inflammation, ischemia/ hypoxia and trophoblast damage.
This work was designed to study the serum level of β-HCG in pre-eclamptic, eclamptic and normotensive pregnant women at third trimester and to correlate level of β-HCG with severity of pre-eclampsia.
The patients were recruited from El-Shatby Maternity University Hospital. They were divided in to four groups, group (Ï): thirty normal pregnant women, group (ÏÏ): thirty mild pre-eclamptic patients, group (ÏÏÏ): thirty severe pre-eclamptic patients and group (ÏV):thirty eclamptic patients.
All patients (n=120) underwent complete history taking, clinical examination, ultrasound examination for fetal biometry, mean gestational age, amount of liquor and Doppler US.
Laboratory investigations were carried out including complete blood count, liver function tests, renal function tests, and complete urine analysis with albumin in urine and serum level of maternal β-HCG.
The results showed that there was no statistical significant difference as regards age, BMI, gestational age and gravidity& parity.
Severe pre-eclamptic and eclamptic groups had significantly higher number and percentage of IUGR with abnormal doppler than normal group but there was no statistical significant difference between mild pre-eclamptic and normal group.
The mean of maternal serum level of β-HCG in pre-eclamptic and eclamptic groups were significantly higher than the normal group, (there was a statistically significant difference between level of β-HCG in mild and control group also between mild and severe pre-eclamptic and between mild and eclamptic groups but there was no statistical significant difference between severe pre-eclamptic and eclamptic group).
Diastolic and systolic blood pressure of severe pre-eclamptic and eclamptic women had a significant positive correlation with serum β-HCG but had non-significant positive correlation with β-HCG in mild PET. However, maternal age had a negative correlation with β-HCG in PET and eclamptic patients.
The pregnant women with fetal growth restriction had significantly higher levels of serum β-HCG than pregnant women with normal fetal growth.