الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The present study was conducted on 100 patients of both sexes who suffered from traumatic brain injury and admitted alive to the Emergency Department (ED) of Alexandria Main University Hospital throughout 2016 to evaluate the functional outcome in cases of traumatic brain injuries using propranolol a non-selective beta blocker
• TBI remains the leading cause of death in trauma patients. Excluding non-survivable head injuries, the cause of death is often due to NNOD, especially cardiac and respiratory manifestations.
• Blocking of the hyperadrenergic response with beta-blockers has been shown to be associated with significant improvements in mortality, most notably in older and more severely injured patients.
• No effective intervention has been found to reverse the pathologic events initiated by the traumatic event.
• Secondary brain injury from progressive intracranial bleeding, cerebral edema, increased intracranial pressure, and subsequent cerebral ischemia is the primary cause of morbidity and mortality after TBI.
• Recently, it appears clear that beta-blockers should play a significant role in future management of TBI and PSS.
• Propranolol has an excellent safety profile and has been shown to be cost-effective. Because of the mechanistic potential for propranolol to decrease secondary brain injury, it has been considered as a possible therapy to improve clinically important outcomes in patients with TBI.
• Patients with pediatrics and infants age groups and with known hypersensitivity to propranolol were excluded from study.
• The aim of the work is to evaluate the role of Beta receptor blockers in the prognosis of traumatic brain injury in Emergency department.
• Primary and secondary survey done for cases on admission, this also include lab tests and CT brain that asses brain findings on admission.
• Patients given propranolol compared to controls had significantly improved GCS in patients with traumatic brain injury but there is no significance decrease in mortality.