الفهرس | Only 14 pages are availabe for public view |
Abstract β-thalassemia syndromes are the most common inherited hemoglobinopathies in the world. Which is caused by an autosomal recessive genetic deficiency in the β-globin chain that leads to accumulation of unpaired α-globin chains. In Egypt It has been estimated that 1000 children out of 1.5 million live births are born annually with thalassemia major, the carrier rate in Egypt has been reported to be in the range of 9%-10% (119). Advances in the care of patients with β-TM, especially with the effective chelating agents that can reduce the iron burden and its consequences, translate into better patient survival, this success has allowed previously unrecognized complications to emerge, including several renal abnormalities. |