الفهرس 
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Abstract
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia due to platelet autoantibodies, causing an accelerated clearance of opsonized platelets by phagocytes. The etiology of ITP remains unclear, both genetic and environmental factors may have a role in the disease development. It has been reported that several gene polymorphisms influence host susceptibility to ITP.
The SNP at TNF-β (+252) is a genetic factor that influence the onset of several distinct autoimmune diseases such as SLE,Graves’ disease and systemic sclerosis.
This study was aimed to investigate the association of single nucleotide polymorphisms (SNP) in the gene of tumor necrosis factor beta (TNF+252G/A) with ITP in Egyptian children patients.
We have analyzed 100 children with ITP (57 males and 43 females) together with 50 healthy unrelated controls, Abo-resh Hospital, Cairo University.
Our result demonstrates that there was no statistical difference in the distribution TNF-β genotypes (AA, GG and AG) between patients and controls. No statistical difference between allelic frequencies (A allele vs. G allele). Furthermore, no association was observed with respect to different categories of ITP or the therapeutic response in ITP patients.
We conclude that there is no association of TNF-β with susceptibility in developing ITP.