الفهرس 
Atherosclerosis andCardiovascular Disease in ESRD
Role of OPN in vascular calcificationOnly 14 pages are availabe for public view
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Abstract
Introduction: Cardiovascular disease (CVD) is the most common cause of morbidity and mortality in dialysis patients. HD patients were shown to exhibit increased intima media thickness (IMT), common carotid plaque, arterial stiffness, and coronary artery calcification and advanced atherosclerosis in the carotid artery compared with age-matched healthy controls,
Aims: 1-To evaluate osteopontin level as a marker for atherosclerosis in chronic hemodialysis patients. 2-To study the correlation between osteopontin and calcium phophorus product.
Patients and Methods: Thesis a descriptive (observentional) study was conducted on (80) chronic heamodialysis patients at Health Insurance hospitals in Gharbia governorate aged above18 years, clinically stable ESRD patients on regular hemodialysis for more than 6 months, 3 sessions /week, 4hour per session by bicarbonate dialysate, Low flux dialyzer with heparin was used as an anticoagulant.
Results: Our study involved eighty (80) chronic hemodialysis patients at Health Insurance hospitals in Gharbia governorate. All the patients were divided according to the serum levels of OPN as tertile classification into 3 groups as following: group 1 (lower tertile) : 29 patients with OPN levels (12-38) ng/ml. group 2 (middle tertile) : 26 patients with OPN levels (40-75) ng/ml. group 3 (upper tertile) : 25 patients with OPN levels (78-270) ng/ml
Conclusion: Elevation of the serum OPN level was associated with both the degree of severity of atherosclerosis estimated by carotid intima-media thickness and degree of diastolic dysfunction , also OPN was associated with the rising of calcium phosphors product in patients undergoing hemodialysis.
Recommendations: We need furthermore interventional studies for OPN as a target therapy by blocking its biosynthesis for prevention and attenuation of atherosclerotic cardiovascular diseases in hemodialysis patients.