الفهرس 
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Abstract
The current study was suggested to isolate and then identify pathogenic fungi from different. It also aims to investigate the pathogenicity of the most sever fungus. Finally, the current study will suggest curing system to inhibit fungal growth either in vitro or in vivo by applying selected marine natural products. Moreover, this study aimed to investigate the bioactive compounds extracted from soft corals, sponge and mangrove to select the most promising crude extracts for further studies.
Fungi colonizing hard coral species collected from Hurghada, Red Sea were isolated and identified to the species level. A total of 47 fungal isolates (37 isolates from hard corals and 10 isolates from other invertebrates) were collected. This resulted in the isolation of 12 fungal species belonging to 4 genera; Aspergillus, Penicillium, Nigrospora and Botrydiploida. Aspergillus and Penicillium were represented by 5 species each whereas, Nigrospora and Botrydiploida were represented by one species each. Pathogenicity of 12 fungal species on Galaxea fascicularis and Stylophora pistillata corals revealed that that the degree of pathogenicity depend up on the fungal species, hard coral species and the duration of exposure to spores. Colonies of G. fascicularis were more susceptible to fungal infection than S. pistillata where they were infected in the first week by spores of four fungi compared to one fungal species for S. pistillata.
The current study was extended to determine the GC-MS of the potent crude extracts as antifungal agents either ethanolic, ethyl acetate or methanol crudes. However, the prevailing compounds were; fatty acids and their derivatives (tetradecanoic acid, ethyl ester and methyl ester of hexadecanoic acid, methyl ester of pentadecanoic acid, methyl ester of octadecenoic acid, methyl ester of tridecanoic acid, Trans-13-octadecenoic acid, methyl ester, and octadecatrienoic acid), terpenoid (Nootkaton-11,12-epoxide, Caryophyllene, Geranyl-a-terpinene, etc.), steroid (Corticosterone, cis-Calamenene, etc.), and others