الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Scar formation is an inevitable consequence of wound healing from either a traumatic or a surgical intervention in which the normal skin is replaced by a fibrous tissue., although Scar formation is beneficial in wound healing, it can create a substantial aesthetic and psychological effects such as emotional debilitation, embarrassment, poor self-esteem, and social isolation.
Many treatment modalities have been proposed for scars with inconstant outcome. One of the most effective and promising procedures to reduce scars and optimize skin appearance is Percutaneous collagen induction (PCI) by Microneedling.
The wound healing properties of Platelet-rich plasma (PRP) has also been applied in treating scars. Activated Platelets release various cytokines and growth factors that promote angiogenesis, tissue remodeling, and wound healing. Moreover, the application of autologous platelet-rich plasma to surgical wounds has been shown to accelerate tissue repair and reduce postoperative pain.
The aim of this study is to compare between the efficacies of microneedling alone (using automated microneedling device) or combined with platelet-rich plasma in the treatment of post-traumatic scars.
This study was carried out on thirty patients complaining of post-traumatic scars. Patients were recruited from the Dermatology outpatient clinic, Alexandria Main University hospital.
Patients were randomly divided into two groups (A, B). Each group included fifteen patients. group A were subjected to four sessions of skin microneedling treatment by automated microneedling device (Dermapen 3™) at two-week intervals. Whereas group B were subjected to four sessions of skin microneedling treatment (Dermapen3™) at two-week intervals similarly but followed by topical application of platelet-rich plasma after each session of microneedling.
All patients in the present study showed improvement. The current study has shown that PRP can significantly affect the final treatment outcome in the management of post-traumatic scars. It showed that when microneedling was combined with topical application of PRP in group B, The degree of improvement was clearly higher than that reported in microneedling alone in group A. this difference was statistically significant where the degree of improvement was 44.99 ± 17.66% in group A and 68.15 ± 13.64% in group B.
The current study showed that there was negative correlation between the % of improvement in response to treatment and the age of the patient in both groups (P value=0.005) which indicates that the younger the age of the patient, the greater the response to treatment. This correlation was statistically significant in group B (P value=0.005). Moreover, There was statistically significant negative correlation between % of improvement in response to treatment and scar duration in both groups (P value<0.001*), denoting that the shorter the duration of the scar the greater the response to treatment.
All patients tolerated the procedure well and no major adverse effects were observed in our study among both groups. The most common adverse effects reported in the immediate
Summary
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post-treatment period were a transient minimal pain and mild transient erythema in all the studied patients in both groups. The present study revealed that when microneedling was combined with topical application of PRP in treatment of post traumatic scars, the degree of improvement was clearly higher than that reported in microneedling alone with no significant adverse effects were reported.