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Abstract Frozen embryo transfer (FET) is assuming a greater role in the practice of infertility than it has in the past. In 2012, 28.4 % of cycles reported to the Society for Assisted Reproductive Technology and the Center for Disease Control and Prevention were frozen embryo transfers compared with 16.1 % in 2003. Aim of the Work The aim of this work is to assess the efficacy ¬¬¬¬¬of endometrial injury before frozen embryo transfer on pregnancy rate. Subjects and Methods: This randomized controlled study was conducted on women planned to undergo frozen embryo transfer¬¬¬ at the ART unit at Faculty of Medicine- Ain Shams University Hospital and Dar el Teb Fertility center from March 2017 to October 2017. Results: The study showed that chemical pregnancy was non-significantly more frequent among EI group than among non-EI group and clinical pregnancy was non-significantly more frequent among EI group than among non-EI group. Conclusion: The result of this study revealed that local mechanical injury to the endometrium before frozen embryo transfer may enhance uterine receptivity and improves the chemical pregnancy rate in women with unexplained infertility. This procedure is safe, easy and with no complications. Recommendations: Further studies are required with a larger number of patients for emphasizing that the local endometrial injury before frozen embryo transfer improves the clinical pregnancy rates. This certainly needs further investigation |