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Abstract More than 80% of women report physical and psychological symptoms especially the hot flushes that commonly accompany peri- menopausal period and so understanding the factors affecting hot flushes is important to decrease the severity of hot flushes and its effects. The objectives of this study were to assess the prevalence and factors affecting hot flushes among peri-menopausal women and the impact of hot flushes on their quality of life in Berket El-Saba district, Menoufia governorate. This study was analytical cross-sectional study which was conducted on 300 females. It included perimenopausal women attended Berket El-Saba family healthcare center (urban area) and Toukh Tanmbisha family health unit (rural area) in Berket El-Saba district, Menoufia governorate, during the period from the beginning of September 2016 up to the beginning of September 2017 with response rate (88.7% and 90.5%) respectively. The studied group were interviewed face-to-face through a predesigned questionnaire to assess personal general characteristics (age, gender, education, occupation, marital status and residence), and assess the severity and the frequency of hot flushes from this study it was found that: 1) The mean age of the studied group was 50.4±2.8 years, most of the studied perimenopausal women were married and of moderate socioeconomic level with BMI ≥ 25 (77%, 85%, 88% respectively), about half of them had secondary level of education, working, from urban area (44.7%,52%,52.3% respectively). 2) The prevalence of hot flushes among the studied perimenopausal females was 86%, about 33.3% represent very severe problematic hot flushes. 3) The most significant factors affecting hot flushes were body mass index ≥ 25 (OR: 42.8, CI; 6.9 -264), followed by basic education (OR: 10.6, CI; 2.6 - 43.4) followed by sedentary life (OR: 3.5, CI; 1.6 - 7.7) and being housewives (OR: 3.2, CI; 1.4 -7.2). 4) There was statistically significant relation between the severity of hot flushes, residence and education and caffeine consumption (p value <0.05). 5) Concerning the quality of life, most of the studied group (76.7%) represent moderate severity of menopause rating scale, there was highly statistically significant positive correlation between severity of hot flushes and menopause rating scale r (0.312) and (p value <0.001). 6) Most of the studied group had mild urogenital symptoms, severe somatic symptoms and mild psychological symptoms. 7) There was statistically significant relation between the occurrence of hot flushes, psychological and somatic subscale of the studied group p value (<0.05, < 0.001 respectively). 8) There was high statistically significant relation between the severity of hot flushes and somatic subscale of the studied perimenopausal females where, (p value <0.001. |