الفهرس 
ContentsOnly 14 pages are availabe for public view
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Abstract
OA is a common, age-related, heterogeneous group of disorders characterized pathologically by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change, and synovitis. The optimal management of knee OA requires a combination of non-pharmacological and pharmacological treatment modalities although unique treatment is still unclear. This study was conducted to evaluate role of vitamin D supplement in osteoarthritic patients. Arandomized controlled trial was conducted in Physical medicine, Rheumatology and Rehabilitation department, Faculty of medicine, Mansoura University. Subject of this study was selected from the outpatient. All patients accepted the consent before enrolled in our study and divided in 3 groups (15 each group) : group I: 15 osteoarthritic patients receiving oral vitamin D supplementation. group II: 15 osteoarthritic patients receiving vitamin D in the form of injection. group III: 15 osteoarthritic patients receiving Placebo. All patients underwent complete clinical examination. As well as, Serum samples are estimated by ELISA technique for serum vitamin D level in the 3 groups. Antero-posterior and lateral weight-bearing semiflexed X-ray was obtained for both knees in each group before starting the study. They are radiologically graded according to the Kellgren-Lawrence Index. Results Before supplement, there was no significant difference in serum vitamin D level in each group. After supplement, high level of serum vitamin D level was detected in group 1 and 2 when compared to group 3. Before supplement; As regard to clinical evaluation of each group before starting supplement treatment, clinical parameters did not show any significant difference (p>0.05). After supplement; pain is significantly lower in group 1 (p=0.009) while functional disability, stiffness and total WOMAC do not show any significant difference between groups (p>0.05). When comparing each group before and after supplement; In group 1 there is significant reduction in pain and functional disability and total WOMAC. In group 2 there is significant reduction in pain, stiffness, functional disability and total WOMAC. In group 3 there are no significant changes. Before supplement, there is insignificant correlation between serum vitamin D level and WOMAC parameters (p>0.05). After supplement, there is a strong negative correlation between serum vitamin D and kellgren Laurence staging (p=0.039) After supplement, There is a significant negative moderate correlation between serum vitamin D level and pain (p=0.040) Conclusion: Our results suggest that knee OA may be associated with decreased levels of vitamin D. Vitamin D supplement help improving knee OA pain, stiffness and total WOMAC. Both oral and injectable vitamin D supplement are effective in increasing serum vitamin D level and improving pain.