الفهرس 
Pneumonia definitionOnly 14 pages are availabe for public view
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Abstract
Authors: Tantawy AA1, Adly AA1, Ali MA2, Kandeil A2, Anwar A3, Kandil ME4, Hamed HM4, Yassin M4.
1Pediatric Department, Ain Shams University, Cairo, Egypt.
2Center of Scientific Excellence for Influenza Viruses, National Research
Center, Giza, Egypt.
3Clinical Pathology Department, Azhar University, Cairo, Egypt.
4 Pediatric Departments, National Research Center, Giza, Egypt.
Corresponding Author: Mohamed Yassin Aly Tel. 01001947971 Email: yassinalydarwish@hotmail.com
Abstract Introduction: Pneumonia stays the main infectious cause of death among children under five. Pneumonia was responsible for 15 % of over whole under-five deaths and killed 920,000 children in 2015. Most of them were less than 2 years of age [1].We performed this study to delineate the spectrum of respiratory viruses causing pneumonia in infants and children less than 3 years in age, and to examine seasonality and clinical manifestations of these infections as well as the relation to disease severity in Egyptian children. Methods: Over a year 62 children less than three years admitted to the Pediatric Hospital, Ainshams University with viral pneumonia were included. All patients were subjected to clinical assessment and had nasopharyngeal swabs for PCR viral detection for the following viruses` genomes: Influenza A, Influenza B, Parainfluenza 1, Parainfluenza 2, Parainfluenza 3, Respiratory Syncytial Virus, Rhinovirus, Adenovirus, Human metapneumovirus (HmPV) and Human Bocavirus (HBoV), CBC, C reactive protein (CRP), and CXR. Results: Viral pathogens were identified in 62 patients (96.8%). The most frequently detected virus was Influenza A in 54 patients (84%) followed by Adenovirus in 28 (44%), then Boca virus in 10 patients (16%) followed by Human metapneumovirus and Rhinovirus each in 8 patients (12.5%). Influenza B, Parainfluenza viruses (PIV1, 2, 3) and Respiratory Syncytial virus were not detected. Coinfection was found in 32 (50%), and 2 cases had unidentified etiology. Majority of cases had non severe and severe respiratory illnesses. 4 patients with multiviral coinfections had very severe respiratory symptoms and were admitted to PICU. Mortality occurred in 3 (4.68%) all with multiviral coinfections. Conclusions: Influenza A was the most commonly detected virus in children less than 3 years admitted with acute lower respiratory tract infections. Coinfection was present in the majority of our patients; this study provides preliminary data regarding the spectrum, seasonality and clinical manifestations of viruses causing CAP in Egyptian infants and preschool children.